Determining the root cause of a failure in a complex system is a demanding task that requires a structured and disciplined approach. From engaging the appropriate subject-matter experts,to verifying the failure in a particular subsystem,to determining the analytical techniques used,this process can be an overwhelming task. The objective of this paper is to describe the approaches and techniques used in a recent case history,and to provide a summary of methods engaged in analyzing the printed wiring assemblies (PWAs) that were involved in the failure. One of the initial steps taken was to assemble a team of subject-matter experts (SMEs) from the various subsystems that comprise the complex system,prior to verifying the failure. During verification of the failure,it was critical that what caused the failure was not disturbed,otherwise critical information leading to the direct cause could be compromised. SME-developed tests were outlined and executed to perform the verification. Once the failure was verified,techniques such as fishbone diagrams were used for causal analysis. The use of root cause tools led the team from a systemic failure,down to a set of PWAs. Once the suspected root cause was determined to be within a particular PWA,a formidable list of analysis techniques were used to narrow down the precise cause. These included,but were not limited to: Bench-top electrical testing,visual examinations,real-time X-ray,Computed Tomography (CT) scans,Printed Circuit Board (PCB) cross-section analysis,scanning electronic microscope (SEM) evaluation,and data package pedigree review. This paper provides a structured,methodical approach to failure analysis and root cause determination for a very complex system. It can be utilized as a guideline for other highly complex systems,or other systems where the cause is suspected to be within a PWA.